Stress Preconditioning of Spreading Depression in the Locust CNS
نویسندگان
چکیده
منابع مشابه
Stress Preconditioning of Spreading Depression in the Locust CNS
Cortical spreading depression (CSD) is closely associated with important pathologies including stroke, seizures and migraine. The mechanisms underlying SD in its various forms are still incompletely understood. Here we describe SD-like events in an invertebrate model, the ventilatory central pattern generator (CPG) of locusts. Using K(+) -sensitive microelectrodes, we measured extracellular K(+...
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Spreading depression (SD) is associated with large changes in extracellular ion concentrations and can be induced by impairing mechanisms of K(+) ion homeostasis. We tested activity dependence of SD in the locust model of ouabain-induced SD in the metathoracic ganglion. Wind activation of thoracic circuitry resulted in small increases of K(+) concentration that took 5-10 s to be cleared from th...
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Spreading depression (SD) is an interesting and important phenomenon due to its role in mammalian pathologies such as migraine, seizures, and stroke. Until recently investigations of the mechanisms involved in SD have mostly utilized mammalian cortical tissue, however we have discovered that SD-like events occur in the CNS of an invertebrate model, Locusta migratoria. Locusts enter comas in res...
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19 Cortical spreading depression (CSD) is able to confer neuroprotection when 20 delivered at least one day in advance of an ischemic event. However, its 21 ability to confer neuroprotection on a more immediate time frame has not 22 previously been investigated. Here we have used mouse neocortical brain 23 slices to study the effects of repeated episodes of CSD in layer V and layer 24 II/III py...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2007
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0001366